Adaptive metabolic reprogramming of the brain tissue during late-stage Trypanosoma brucei infection maintains host learning and memory
Nadin Fathallah, Chloe Barnes, Rebecca Chatwin, Jayde Whittingham‐Dowd, John J. Worthington, Lucy Helen Jackson-Jones, Neil Dawson, Michael D. Urbaniak
This study shows that during stage II of HAT infection, the brain reprograms its metabolism to use fatty acids and lipids instead of glucose, maintaining cognitive functions despite metabolic changes.
bioRxiv · May 21, 2026 · PreprintImmunology