Newly regenerated axons through a cell-containing biomaterial scaffold promote reorganization of spinal circuitry and restoration of motor functions with epidural electrical stimulation.
Ahad M. Siddiqui, Riazul Islam, Carlos A. Cuellar, Jodi L. Silvernail, Bruce E. Knudsen, Dallece E. Curley, Tammy Strickland, Emilee Manske, Parita T. Suwan, Timur H. Latypov, Nafis Akhmetov, Shuya Zhang, Priska Summer, Jarred J. Nesbitt, Bingkun K. Chen, , Igor Aleksandrovich Lavrov
This study shows that a cell-containing biomaterial scaffold promotes axon regeneration and spinal circuit reorganization, enhancing motor function recovery when combined with epidural electrical stimulation after spinal transection.
bioRxiv · Sep 9, 2020 · PreprintNeuroscience