Bruce E. Knudsen

This study identifies off-target neural pathways activated during carotid baroreceptor stimulation in swine, contributing to side-effects of baroreflex activation therapy.

This study shows that sympathetic fibers are present in the rat cervical vagus nerve and that stimulating the vagus nerve can activate these fibers, leading to tachycardia rather than bradycardia.

This study identifies and characterizes sources of artifact contaminating evoked compound action potentials (ECAPs) in epidural spinal cord recordings, highlighting challenges in distinguishing neural signals from artifacts in a swine model.

This paper demonstrates the use of intraoperative ultrasound to visualize pig vagus nerve fascicular organization (vagotopy) and improve cuff placement for vagus nerve stimulation.

This study provides the first detailed analysis of segment-specific dorsal and ventral spinal roots orientation in humans, correlated with spinal cord and vertebral landmarks.

This study shows that a cell-containing biomaterial scaffold promotes axon regeneration and spinal circuit reorganization, enhancing motor function recovery when combined with epidural electrical stimulation after spinal transection.

This study uses functional ultrasound imaging to show that spinal cord hemodynamic responses to epidural stimulation reflect changes in spinal circuitry organization based on stimulation parameters.

The paper identifies specific neuroanatomical pathways causing off-target effects of vagus nerve stimulation in pigs and characterizes dose-response curves for on- and off-target effects.

The paper characterizes the anatomy of the cervical vagus nerve in domestic pigs, identifying structural features relevant to vagus nerve stimulation and comparing them across species.