Paneth cell-derived Notch ligands DLL1 and DLL4 are crucial for intestinal crypt base stem cells.
Michaela K. Quintero, Theresa M. Keeley, Justin A. Colacino, Nan Gao, Peter J. Dempsey, Linda C. Samuelson
This study shows that Paneth cell-derived Notch ligands DLL1 and DLL4 are essential for maintaining intestinal crypt base stem cells and their regeneration after injury.
bioRxiv · Sep 16, 2026 · PreprintCell Biology