Justin A. Colacino

This study shows that DDE exposure alters cell state and stem cell markers in breast cells, inducing an epidermal phenotype and upregulating keratinization pathways.

This study shows that Paneth cell-derived Notch ligands DLL1 and DLL4 are essential for maintaining intestinal crypt base stem cells and their regeneration after injury.

The paper investigates sex-specific molecular responses to early-life toxicant exposures in mice across multiple life stages using transcriptomic and epigenomic data.

This study shows that PFOA exposure during cardiomyocyte differentiation alters gene expression and electrophysiological function in hiPSC-CM, with effects lasting after exposure stops.

This study shows that lead exposure during human iPSC-derived cardiomyocyte differentiation alters gene expression and pathway dysregulation, with persistent transcriptional changes even after exposure stops.

This study investigates how chemical exposures affect biological processes linked to aggressive breast cancer using transcriptomic analysis of normal breast cells from diverse donors.

This study identifies RUNX2 as a regulator of WNT signaling in UC by analyzing snRNA-seq and snATAC-seq data from UC patient-derived colonoids.

This study shows that perinatal lead exposure increases mouse embryonic weight and alters gene expression in neuronal and sexually dimorphic pathways.

The paper characterizes persistent epigenomic and transcriptomic changes in mice exposed to environmental toxicants across life stages, revealing widespread gene expression and chromatin alterations.

This study examines how environmentally relevant lead exposure affects gene expression in SH-SY5Y cells during neuronal differentiation, finding stage-specific and persistent changes in gene expression and pathway enrichment.

This study examines how different levels of lead exposure affect neural differentiation in SH-SY5Y cells, showing significant changes in protein expression and cell morphology.

The paper develops a DNA methylation reference panel for placental tissues to estimate cell composition from bulk DNAm data, showing improved performance over existing methods.

The paper uses Cell Painting to assess the morphological effects of 16 chemicals and 21 small molecules on MCF10A cells, identifying shared and distinct features and linking some to Wnt pathway activation.

This study examines how perinatal exposure to lead or DEHP affects age-related DNA methylation and gene expression in mouse hearts, revealing sex-specific differences.

The paper deconvolves placental gene expression data to show cell type proportions drive preeclampsia gene expression differences, reducing differentially expressed genes after adjustment.

This study analyzes racial disparities in chemical biomarker concentrations among US women, identifying persistent exposure differences for pesticides, parabens, and metals across race/ethnicity and age groups.

This study shows perinatal lead exposure causes sex-specific DNA methylation changes in adult mouse liver and blood, with some methylation sites overlapping between tissues.

This paper benchmarks information-theoretic feature selection methods against differential expression methods in scRNA-seq to identify efficient gene sets for cell type differentiation.

The paper introduces a gene filtering method for comparing single-cell RNA-seq trajectory datasets, showing improved performance over existing methods.

The paper uses single-cell RNA sequencing to analyze ALDH+ and CD44+CD24- populations in normal human breast tissue, revealing heterogeneity and hybrid epithelial/mesenchymal cells with stemness and EMT features.