Peter J. Dempsey

This study shows that Paneth cell-derived Notch ligands DLL1 and DLL4 are essential for maintaining intestinal crypt base stem cells and their regeneration after injury.

This study shows that nuclear mechanics influence intestinal stem cell differentiation by sensing tissue shape and modulating lamin-A levels.

This study shows that a synthetic hydrogel enables crypt formation in intestinal organoids without exogenous laminin, revealing insights into mechanical and matricellular signaling.