Hypoxia modulates human pulmonary arterial adventitial fibroblast phenotype through HIF-1α activation
Jennifer L. Philip, Christine A. Caneba, Laura R. Caggiano, Nandhini Prakash, Tik-Chee Cheng, Katherine A. Barlow, Tasneem Mustafa, Diana Marcela Tabima, Timothy A. Hacker, Kristyn S. Bohl Masters, Naomi C. Chesler
This study investigates how hypoxia affects human pulmonary arterial adventitial fibroblasts through HIF-1α activation, showing increased collagen and decreased MMP2 activity.
bioRxiv · Jan 27, 2025 · PreprintBioengineering