Naomi C. Chesler

This paper develops a multiscale computational model to simulate cardiopulmonary effects of postnatal hyperoxia in rats, showing agreement with experimental data and capturing abnormalities seen in preterm humans.

This study identifies a sexually dimorphic NLRP3 signaling pathway in right ventricular failure, showing estrogen receptor α mediates protection against NLRP3-induced contractile dysfunction in cardiomyocytes.

This study shows that Ca2+ increases cardiac muscle viscoelasticity independently of active force development, with a >6-fold increase in apparent viscoelasticity at higher Ca2+ levels.

This study investigates how hypoxia affects human pulmonary arterial adventitial fibroblasts through HIF-1α activation, showing increased collagen and decreased MMP2 activity.