Integrated Patient-Derived Xenograft and Patient-Derived Cell Models Reveal Therapeutic Vulnerabilities Beyond Standard-of-Care Therapy in Endometrial Cancer
Tianyue Li, Fang Huang, XJ Huang, Ella I Pate, Riley Rosenmeyer, Mya Messenger, Kaylee McSweeney, Samuel Robinson, Adam Deters, Lauren Buchanan, Maggie Meehan, Nandini Patel, Allison Diekema, Yiqin Xiong, X Zhang, , Shujie Yang
This study establishes a PDX and PDC platform to identify therapeutic vulnerabilities in endometrial cancer, revealing that epigenetic combination therapies show significant antitumor activity.
bioRxiv · Jul 27, 2026 · PreprintCancer Biology