X Zhang

Integrated Patient-Derived Xenograft and Patient-Derived Cell Models Reveal Therapeutic Vulnerabilities Beyond Standard-of-Care Therapy in Endometrial Cancer

This study establishes a PDX and PDC platform to identify therapeutic vulnerabilities in endometrial cancer, revealing that epigenetic combination therapies show significant antitumor activity.

Label-free Pathogen Identification with Microscopy Imaging and Deep Learning

This paper develops a label-free imaging and deep learning approach to rapidly identify pathogens, achieving high accuracy in clinical samples and reducing diagnosis time.

Early Life Stress induces brain-wide electrical network predisposition to migraine

This study shows early life stress increases vulnerability to migraine by altering brain network activity in response to CGRP.

Tabular foundation model predicts alternative lengthening of telomeres (ALT) and identifies SMARCAL1 as a target in ALT-driven cancers

The paper develops ALTitude, a machine learning model to predict ALT status from whole genome sequencing data, identifies SMARCAL1 as a therapeutic target in ALT-driven cancers.

The inflammatory micro-environment induced by targeted CNS radiotherapy is underpinned by disruption of DNA methylation

This study shows that targeted CNS radiotherapy disrupts DNA methylation and induces neuroinflammation through epigenetic changes in brain tissue and cerebral organoids.