Frataxin deficiency in the astrocytes drives neurocognitive impairment in sickle cell disease mice
Enrico Maria Novelli, Shane C Lenhart, Lesley M. Foley, Nandinii Sekar, Paritosh Mondal, Hong Wang, T. Kevin Hitchens, Samit Ghosh, Stephen Y. Chan, Xiaoming Hu, Rimi Hazra
This study shows that frataxin deficiency in astrocytes worsens cognitive impairment in sickle cell disease mice, suggesting FXN as a potential therapeutic target.
bioRxiv · Dec 20, 2024 · PreprintNeuroscience