Stephen Y. Chan

The paper identifies pulmonary primary oxysterol and bile acid synthesis as a prognostic biomarker for pulmonary arterial hypertension, outperforming current clinical risk scores.

This study identifies LDHA-lactate-induced over-lactylation and TOP1 accumulation as drivers of PASMC hyper-proliferation and PAH, with TOP1 inhibition reversing these effects.

This study shows poor sleep worsens pulmonary arterial hypertension (PAH) by inducing inflammation and PASMC proliferation, forming a self-amplifying cycle that can be mitigated by improving sleep and reducing inflammation.

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

This study shows that frataxin deficiency in astrocytes worsens cognitive impairment in sickle cell disease mice, suggesting FXN as a potential therapeutic target.

This study shows IFI16, regulated by m6A modification, drives inflammatory endothelial changes in pulmonary arterial hypertension.

This study investigates how the PLN R9C mutation affects iPSC-CMs and shows that promoting autophagy can mitigate stress-induced structural and functional defects in these cells.

Open-source KBase platform unites reference genomes and biochemistry, over 70 apps, Jupyter-based Narratives with provenance, and a Docker SDK for reproducible plant and microbial systems biology.