The Specificity of IQGAP1 Toward the PI3K-Akt Pathway is Dependent on the IQ3 motif
Mo Chen, Tianmu Wen, Suyong Choi, Narendra Thapa, Oisun Jung, Paul F. Lambert, Alan C. Rapraeger, Richard A. Anderson
This study identifies the IQ3 motif in IQGAP1 as critical for specific PI3K-Akt pathway scaffolding, without affecting Ras-ERK pathway functions or cell migration.
bioRxiv · Jan 24, 2018 · PreprintCell Biology