Tianmu Wen

Lipid Transfer Proteins and PI4KIIα Generate a Phosphoinositide-Linked Proteome

The paper identifies a PIPn-linked proteome in membrane-free regions, showing that PITP/β and PI4KIIα generate protein-PIPn complexes involved in metabolic and signaling pathways.

Regulation of the MDM2-p53 Nexus by a Nuclear Phosphoinositide and Small Heat Shock Protein Complex

This study identifies a role for nuclear phosphoinositides in regulating MDM2 stability and function through interactions with small heat shock proteins, offering a new therapeutic target in cancer.

Regulation of the poly(A) Polymerase Star-PAP by a Nuclear Phosphoinositide Signalosome

This study shows that Star-PAP is regulated by phosphoinositides in response to stress through interactions with PITP/{beta}, PI kinases/phosphatases, and HSP27.

The Specificity of IQGAP1 Toward the PI3K-Akt Pathway is Dependent on the IQ3 motif

This study identifies the IQ3 motif in IQGAP1 as critical for specific PI3K-Akt pathway scaffolding, without affecting Ras-ERK pathway functions or cell migration.