Identification and Mechanistic Characterization of a Novel Peptide Inhibitor of Glycogen Synthase Kinase (GSK3) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein
Stephanie L. Saundh, Debasis Patnaik, Steve Gagné, Joshua A. Bishop, Sean Lipsit, Samat Amat, Narsimha Pujari, Anand Krishnan Nambisan, Robert M. Bigsby, Mary Murphy, Li‐Huei Tsai, Stephen J. Haggarty, Adelaine Kwun-Wai Leung
This study identifies and characterizes a novel 44-mer peptide from DISC1 that inhibits GSK3β in a non-competitive manner, offering a new approach for developing selective GSK3β inhibitors.
ACS Chemical Neuroscience · Nov 30, 2020Peer-reviewedNeuroscience