Spatial transcriptomics defines the mechanisms of hiPSC derived stem cell mediated repair in human articular cartilage
Y.F. Ramos, Sayedeh Sana Sayedipour, Georgina Shaw, Margo Tuerlings, Timo Schomann, H. Eka D. Suchiman, Davy Cats, Frank Barry, Rachid Mahdad, Hailiang Mei, Luis Javier Cruz, Mary Murphy, Ingrid Meulenbelt
The paper evaluates the therapeutic effects of hiMSCs in osteoarthritis models, showing reduced damage and activation of cholesterol pathways, with spatial transcriptomics revealing localized molecular changes.
bioRxiv · Jul 23, 2026 · PreprintDevelopmental Biology