Li‐Huei Tsai

This study integrates multi-omic data from mouse and human choroid plexus to identify conserved molecular programs of epithelial function across species.

The paper introduces ExRPath and 15ExMPath techniques to expand human brain tissue for nanostructure analysis, revealing amyloid nanoclusters associated with SARS-CoV-2 in COVID-19 patients.

This study shows that p53 activation via DNA damage response causes aberrant neuronal activity in neurodegenerative diseases, and inhibiting p53 reduces this activity in a human iPSC model.

The paper identifies a vulnerable astrocyte state in the prefrontal cortex of Down syndrome-associated Alzheimer's disease through integrated single-nucleus RNA-seq and ATAC-seq analysis.

This paper presents a neurorecording toolkit to longitudinally assess transplanted human cortical organoids in vivo, showing increased neuronal activity and synchronicity over time.

The paper constructs a 3D human brain model integrating multiple cell types to study Alzheimer's Disease mechanisms linked to APOE4.

The paper identifies Wnt signaling defects and GSK3b overactivity as regulators of lipid accumulation in APOE4 oligodendrocytes, showing that inhibiting GSK3b reduces lipid droplets and improves myelination.

This study identifies an inflammation-driven gene module in brain endothelial cells that compromises BBB integrity in Alzheimer's disease and shows that an NF-κB inhibitor can reverse these effects.

The paper develops a 3D Brain-Chip system using human iPSC-derived cells to model the BBB and study APOE4's role in Alzheimer's disease.

The paper identifies context-dependent regulatory variants in Alzheimer's disease by analyzing their effects across different cellular contexts using MPRAs and machine learning.

This study integrates multi-omics data from Drosophila and human Alzheimer's disease models to identify pathways involved in neurodegeneration.

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

The paper shows that combining CSF1R inhibition with GENUS stimulation improves cognitive function in Alzheimer's mice by restoring neural circuitry and gene expression.

This study shows that multisensory gamma stimulation improves cognitive function and adult neurogenesis in Ts65Dn mice, a model of Down syndrome.

The paper introduces umExM, a method for dense membrane labeling and expansion microscopy to achieve nanoscale visualization of membranes in tissues, demonstrating resolution down to ~35 nm.

This study identifies molecular and cellular signatures of cognitive resilience in Alzheimer's disease by integrating multi-omics data from brain tissues.

This study shows that cholinergic signaling is crucial for GENUS-induced perivascular amyloid clearance in Alzheimer's mouse models.

This study identifies Pla2g2f as a neuroprotective factor that maintains lipid homeostasis and mitigates aging-associated cognitive decline in a mouse model of Alzheimer's disease.

The paper discusses findings on 40 Hz sensory stimulation's effects on the brain, supporting its potential benefits while noting technical limitations in amyloid burden studies.

This study identifies ABCA7 loss-of-function variants' impact on phosphatidylcholine metabolism in human neurons and shows CDP-choline can reverse these effects.

The paper profiles H3K27ac in brain cell types from AD patients and finds acetylation differences in oligodendrocytes linked to AD risk genes and pathways.

This study compares the effects of TREM2 R47H/+ and T66M mutations on iPSC-derived microglia, finding distinct gene expression and functional changes linked to neurodegeneration.

The paper introduces MorphOMICs, a topological data analysis method to identify sex- and region-dependent microglial morphological phenotypes across development and neurodegeneration.

The paper identifies that DNA double strand breaks in neurons activate immune pathways, leading to microglia activation in neurodegeneration.

This study shows that APOE4 in microglia causes lipid accumulation, impairing their ability to monitor neuronal activity and leading to disrupted neuronal network function.

This study analyzes somatic mosaicism in Alzheimer's Dementia using single-cell data, finding increased mutational burden in specific cell types and genes associated with disease processes.

The paper identifies cell-type-specific molecular changes in cerebrovascular cells across brain regions in Alzheimer's Disease, linking them to genetic variants and potential therapeutic targets.

The paper profiles DNA break sites and transcriptional changes in the brain after contextual fear learning in mice, finding widespread DSBs linked to gene expression in both neurons and glia.

The paper uses single-cell transcriptomics to analyze the hippocampus and entorhinal cortex in Alzheimer's disease, identifying stage-specific molecular changes across cell types.