S100A9 interacts with a dynamic region on CD14 to activate Toll-like receptor 4.
Lauren O. Chisholm, Natalie M. Jaeger, Hannah E. Murawsky, Michael J. Harms
This study identifies how S100A9 interacts with CD14 to activate TLR4, showing CD14-dependent TLR4 internalization and a dynamic binding site on CD14 that overlaps with LPS binding.
bioRxiv · May 15, 2024 · PreprintBiochemistry