Lauren O. Chisholm

This study shows that expanding training data diversity with synthetic gene libraries improves machine learning models' ability to generate functional fluorescent proteins beyond natural sequence space.

This paper engineers affibodies with tunable affinities for VEGF and PDGF using computational design and yeast display to improve controlled protein release from hydrogels.

This study shows that recombinant S100A9 expressed in insect cells lacks TLR4 activation compared to E. coli-expressed S100A9, due to altered oligomerization.

This study identifies how S100A9 interacts with CD14 to activate TLR4, showing CD14-dependent TLR4 internalization and a dynamic binding site on CD14 that overlaps with LPS binding.