Geometry-dependent mRNA delivery with programmable RNA-DNA nanostructures
Mengxi Zheng, Abhisek Dwivedy, Dhanush Gandavadi, Wei Hong, Hyeongjun Cho, Natalie Shkolnik, Xing Wang
This study develops a modular RNA-DNA nanoplatform to investigate how carrier geometry affects mRNA delivery efficiency and provides insights into structure-function relationships in nucleic acid delivery.
bioRxiv · Sep 22, 2026 · PreprintBioengineering