Xing Wang

This study develops a modular RNA-DNA nanoplatform to investigate how carrier geometry affects mRNA delivery efficiency and provides insights into structure-function relationships in nucleic acid delivery.

The paper introduces CASCAD, a DNA nanoplatform that reconstitutes supramolecular protein function, specifically apoptosome activity, through programmable assembly of caspase recruitment domains.

This paper demonstrates the isothermal assembly of DNA nanostructures and 3D crystals in hydrated ionic liquids, enhancing biostability and enabling cell internalization without thermal annealing.

AptaBLE is a deep learning framework that predicts aptamer-protein binding and generates novel aptamers with high specificity and low Kd values.

This paper introduces a reusable high-throughput microfluidic platform with modular design and reversible bonding, enabling rapid and scalable biological experiments.

APIPred Web 1.0 predicts aptamer sequences for protein targets using machine learning and structural analysis, generating experimentally usable candidates with high specificity.

This paper develops a DNA nanostructure platform for ultrasensitive HIV-1 detection and antiviral activity, showing improved binding affinity and diagnostic performance.

This paper develops hybrid peptide-DNA nanomaterials that neutralize influenza viruses more effectively than free peptides by enhancing multivalent binding and reducing toxicity.

This paper develops a 2D DNA origami platform to spatially arrange nanobodies for enhanced antiviral activity against coronaviruses and retroviruses.

This study investigates DNA nanostructure assembly in various cations, showing successful assembly in Ca2+, Ba2+, Na+, K+, and Li+ with improved nuclease resistance in monovalent ions.

This study identifies saracatinib as a potential anti-fibrotic drug effective in multiple models of pulmonary fibrosis, showing equal or superior efficacy compared to existing treatments.

The paper validates prostate cancer risk SNPs using CRISPR/Cas9 to show they alter MSMB expression, highlighting the importance of functional studies in GWAS findings.