Dhanush Gandavadi

This study develops a modular RNA-DNA nanoplatform to investigate how carrier geometry affects mRNA delivery efficiency and provides insights into structure-function relationships in nucleic acid delivery.

The paper introduces CASCAD, a DNA nanoplatform that reconstitutes supramolecular protein function, specifically apoptosome activity, through programmable assembly of caspase recruitment domains.

This paper demonstrates the isothermal assembly of DNA nanostructures and 3D crystals in hydrated ionic liquids, enhancing biostability and enabling cell internalization without thermal annealing.

AptaBLE is a deep learning framework that predicts aptamer-protein binding and generates novel aptamers with high specificity and low Kd values.

APIPred Web 1.0 predicts aptamer sequences for protein targets using machine learning and structural analysis, generating experimentally usable candidates with high specificity.

This paper develops hybrid peptide-DNA nanomaterials that neutralize influenza viruses more effectively than free peptides by enhancing multivalent binding and reducing toxicity.

This study investigates DNA nanostructure assembly in various cations, showing successful assembly in Ca2+, Ba2+, Na+, K+, and Li+ with improved nuclease resistance in monovalent ions.