Assessing scoring metrics for AlphaFold2 and AlphaFold3 protein complex predictions
Luca R. Genz, Sanjana Anilkumar Nair, Natan Nagar, Maya Topf
This study evaluates scoring metrics for AlphaFold2 and AlphaFold3 protein complex predictions, finding that interface-specific scores like ipTM and model confidence are most reliable, and introduces a new combined score, C2Qscore, to improve assessment.
Protein Science · Oct 13, 2025Peer-reviewedBioinformatics