Luca R. Genz

ProNA3D analyzes nucleic acid-containing interfaces in protein-nucleic acid and nucleic acid-only complexes, providing tools for visualization, scoring, and dynamic complex evaluation.

This study evaluates scoring metrics for AlphaFold2 and AlphaFold3 protein complex predictions, finding that interface-specific scores like ipTM and model confidence are most reliable, and introduces a new combined score, C2Qscore, to improve assessment.

PICKLUSTER identifies sub-interfaces in protein-protein complexes using distance clustering to improve targeting of large interfaces.