Maya Topf

This study uses cryo-EM to reveal drebrin's structural interaction with F-actin through two domains, explaining its modulatory role in actin networks and competitive binding with other proteins.

ProNA3D analyzes nucleic acid-containing interfaces in protein-nucleic acid and nucleic acid-only complexes, providing tools for visualization, scoring, and dynamic complex evaluation.

This study evaluates scoring metrics for AlphaFold2 and AlphaFold3 protein complex predictions, finding that interface-specific scores like ipTM and model confidence are most reliable, and introduces a new combined score, C2Qscore, to improve assessment.

ChemEM docks small molecules into medium-resolution cryo-EM maps using difference maps and a scoring function, outperforming existing methods and demonstrating utility at low resolutions.

The paper evaluates CASP15 cryoEM predictions using density maps, showing high accuracy but challenges in side-chain positioning and loop modeling.

PICKLUSTER identifies sub-interfaces in protein-protein complexes using distance clustering to improve targeting of large interfaces.

The paper identifies key genes involved in regeneration in axolotl limbs by comparing transcriptomic data from juvenile and aged axolotls.

The paper reveals the molecular mechanism of an insecticidal protein through 3D structures of its three main pore formation states.

GOAT is a deep learning tool for annotating organoids from microscopy images, showing high performance across diverse organoid systems.

The paper introduces PI-score, a machine learning-based metric to assess protein-protein interfaces in cryo-EM-derived assemblies, identifying errors not captured by density-based methods.

The paper introduces MoDS, a score for assessing protein structure models using monolink data, and shows combining it with MNXL improves model scoring, supporting the use of monolink data in integrative structure determination.

This study uses consensus clustering of HSV1 protein interaction networks to uncover evolutionary links between herpesviruses and bacteriophages, identifying pUS10 as a potential evolutionary vestige.

The paper examines the genetic diversity of CHC22 clathrin and its impact on glucose metabolism, finding that a variant is less effective at controlling GLUT4 traffic and is more common in farming populations.