Periplasmic detoxification of urate hydroperoxide underpins E. coli survival in the inflamed gut
Maxence S. Vincent, Laurent Loiseau, Matthew Jones, Pierre Stocker, Khalid El Karkouri, Marion Chéry, Divya Choudhary, Nicolas Vidal, Maria G. Winter, Natasha W. Tanner, Sylvia Pietri, Sebastian Winter, Benjamin Ezraty
This study identifies HiuH as a periplasmic enzyme in E. coli that detoxifies urate hydroperoxide, enhancing bacterial survival in inflamed gut conditions.
bioRxiv · Jun 2, 2026 · PreprintMicrobiology