Genetic Manipulation of Caveolin-1 in the Mouse Model of Marfan Syndrome Associated Aortic Root Aneurysm: Effects on Endothelial and Smooth Muscle Function
Tala Curry, Brikena Gusek, Ross M. Potter, T. Bucky Jones, Raechel Dickman, Nathan Johnson, John N. Stallone, Roshanak Rahimian, Johana Vallejo‐Elias, Mitra Esfandiarei
This study investigates the role of caveolin-1 in aortic root aneurysm development in MFS mice by examining its effects on endothelial and smooth muscle function, showing that Cav1 ablation increases NO production and improves aortic wall structure.
International Journal of Molecular Sciences · Nov 26, 2024Peer-reviewedPhysiology