Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation
Caroline Jia, Andrea Tran, Faith Aloboudi, Ella Say, Nick Thao, Christopher R. Lee, Kanha Batra, Amanda Nguyen, Aneesh Bal, Nathaniel N. Nono, Jeremy Delahanty, May G. Chan, Laurel R. Keyes, Reesha R. Patel, Romy Wichmann, , Kay M. Tye
This study shows social exclusion increases physical pain responses through insular neuromodulation in mice, with opposing endocannabinoid and oxytocin signaling.
bioRxiv · May 9, 2025 · PreprintNeuroscience