Kay M. Tye

Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors

The paper identifies the amygdalostriatal transition zone (ASt) as a critical structure for encoding sustained cue responses that guide defensive behaviors.

Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice

This study identifies a BLA-mPFC neural pathway through which social isolation increases alcohol drinking in male mice by altering prefrontal cortex activity.

Long-term editing of brain circuits in mice using an engineered electrical synapse

The paper engineers an electrical synapse in mice using fish connexins to modulate neural circuits and behavior.

Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State

The paper identifies distinct roles of three DRN dopamine neuron projections in social behavior and affective states through optogenetic and electrophysiological experiments.

Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation

This study shows social exclusion increases physical pain responses through insular neuromodulation in mice, with opposing endocannabinoid and oxytocin signaling.

Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression

The paper predicts stress-induced anhedonia by analyzing cortical dynamics and facial expressions in mice, showing that mPFC valence encoding and behavior can predict susceptibility.

Control of innate olfactory valence by segregated cortical amygdala circuits

The paper identifies a topographic organization in the posterolateral cortical amygdala (plCoA) that controls innate olfactory attraction and aversion through distinct cell types and projections.

An unbiased method to partition diverse neuronal responses into functional ensembles reveals interpretable population dynamics during innate social behavior

The paper introduces a statistical framework to cluster neural activity into functional ensembles, demonstrating its application to social behavior data in rodents and primates.

Reward contingency gates selective cholinergic suppression of amygdala neurons

This study shows that basal forebrain cholinergic activation modulates amygdala neuron activity based on reward contingency, affecting conditioned behavior but not unconditioned responses.

Thalamus sends information about arousal but not valence to the amygdala

The paper investigates the role of the MGN-BLA circuit in associative learning, finding that the MGN encodes arousal but not valence, while the BLA encodes both.

Neuromodulators generate multiple context-relevant behaviors in a recurrent neural network by shifting activity flows in hyperchannels

This paper shows how neuromodulators alter neural network behavior by shifting activity flows through hyperchannels, enhancing computational flexibility in a recurrent neural network model.

Acute social isolation causes midbrain craving responses similar to hunger.

The paper shows that acute social isolation leads to midbrain activation similar to hunger, correlating with social craving.

A modeling framework for adaptive lifelong learning with transfer and savings through gating in the prefrontal cortex

This paper introduces a neural network framework called DynaMoE to model how the prefrontal cortex encodes, stores, and switches between schemas, demonstrating transfer learning and memory savings.

Precision calcium imaging of dense neural populations via a cell body-targeted calcium indicator

The paper develops cell body-targeted calcium indicators to improve signal fidelity in one-photon imaging of neural activity in live mice and zebrafish.

Acute Food Deprivation Rapidly Modifies Valence-Coding Microcircuits in the Amygdala

The paper shows that food deprivation rapidly shifts the balance between BLA neurons projecting to NAc and CeM, altering valence coding and reward motivation.

Acute stress induces long-lasting alterations in the dopaminergic system of female mice

This study shows that acute stress in female mice leads to long-lasting changes in dopaminergic system function and behavior.