Novel Transgenic Humanized Alpha-1 Antitrypsin Deficiency Mouse Model on Murine SERPINA1 Null Background
Regina A. Oshins, Alek M. Aranyos, Skylar Grey, Naweed S. Mohammad, Yuanqing Lu, Jorge E. Lascano, Tammy O. Flagg, Karina A. Serban, Mark Brantly, Nazli Khodayari
This paper develops a humanized transgenic mouse model for AATD with a SERPINA1-null background, showing liver disease features and supporting its use for studying the disease and drug discovery.
bioRxiv · Oct 11, 2024 · PreprintMolecular Biology