Depletion of limiting rDNA structural complexes triggers chromosomal instability and replicative aging of Saccharomyces cerevisiae
Ryan D. Fine, Nazif Maqani, Mingguang Li, Elizabeth Franck, Jeffrey S. Smith
The paper shows that depletion of cohesin and other nucleolar chromatin factors in aged yeast cells leads to chromosomal instability and reduced replicative lifespan.
Genetics · Mar 6, 2019Peer-reviewedGenetics