Ryan D. Fine

BxbI-mediated insertion of a 77kb human RET sensitive haplotype into the mouse genome to generate a humanized model of Hirschsprung disease

This study inserts a human RET haplotype into mice to model Hirschsprung disease, finding that regulatory variants reduce RET expression and contribute to disease.

Joint disruption of Ret and Ednrb transcription drives cell fate reversal in the Enteric Nervous System in Hirschsprung disease

This study shows that reduced function alleles in Ret and Ednrb genes cause Hirschsprung disease by disrupting their gene regulatory network and leading to cell fate reversal in the enteric nervous system.

Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III

The paper identifies Fob1-dependent condensin recruitment and loop extrusion at the RDT1 locus on yeast chromosome III, linking it to MATa-specific organization during mating-type switching.

A Sir2-regulated locus control region in the recombination enhancer of Saccharomyces cerevisiae specifies chromosome III structure

This paper identifies a Sir2-regulated locus control region in the recombination enhancer of yeast that controls chromosome III structure and mating-type switching.

Depletion of limiting rDNA structural complexes triggers chromosomal instability and replicative aging of Saccharomyces cerevisiae

The paper shows that depletion of cohesin and other nucleolar chromatin factors in aged yeast cells leads to chromosomal instability and reduced replicative lifespan.