Jeffrey S. Smith

The paper uses Nanopore and Illumina sequencing to study age-related changes in yeast tRNA modifications and CCA-tail dynamics.

The paper identifies topoisomerase I (Top1) depletion in aging yeast cells and shows its impact on rDNA silencing and replicative lifespan.

The paper identifies Fob1-dependent condensin recruitment and loop extrusion at the RDT1 locus on yeast chromosome III, linking it to MATa-specific organization during mating-type switching.

This paper identifies a Sir2-regulated locus control region in the recombination enhancer of yeast that controls chromosome III structure and mating-type switching.

The paper shows that depletion of cohesin and other nucleolar chromatin factors in aged yeast cells leads to chromosomal instability and reduced replicative lifespan.