Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition
Neel Shanmugam, Shubham Chatterjee, Gerardo Andrés Cisneros
This study examines how the V762A PARP1 mutation affects binding of three PARP inhibitors, finding that talazoparib binds more effectively to the mutant and alters its dynamics differently than the wild-type.
The Journal of Physical Chemistry B · Feb 18, 2025Peer-reviewedBiophysics