Gerardo Andrés Cisneros

This paper identifies separate metal-binding sites in Pol γ that regulate its DNA synthesis and strand displacement activities, revealing structural and biochemical mechanisms for mitochondrial DNA replication.

This paper investigates how a cancer-associated mutation and serine phosphorylation affect the structure and function of PARP2, showing that PTMs can mitigate the mutation's structural impact.

The paper investigates the role of the [4Fe-4S] cofactor in MUTYH DNA repair by analyzing cancer variants and solving the enzyme's crystal structure.

This study examines how the V762A PARP1 mutation affects binding of three PARP inhibitors, finding that talazoparib binds more effectively to the mutant and alters its dynamics differently than the wild-type.

The paper analyzes POT1 variants in a melanoma case-control cohort, finding that pathogenic variants are a minor contributor to melanoma risk but should be screened in high-risk individuals.