Tumor-Derived SPP1 Drives Immunosuppressive Macrophage Reprogramming in Gastric Peritoneal Carcinomatosis
Lilia M. Turcios, Neelima Hosamani, Ellen J. Beswick, Eric Ubil, Maria Carey, Joshua Leinwand, Sachiyo Nomura, Jun Yan, Bernard Mark Evers, Joseph Kim, Mautin Barry-Hundeyin
This study identifies SPP1 as a tumor-derived factor that reprograms macrophages to suppress immunity in gastric peritoneal carcinomatosis, showing SPP1 inhibition reduces metastasis.
bioRxiv · Jun 24, 2026 · PreprintCancer Biology