FANCM restrains structural genome evolution and defines a synthetic lethal dependency in BRCA1-deficient breast cancer
Farah Ramadan, Sameer Bikram Shah, Ujwal Subedi, Zachary D. Stephens, Annapoorna Venkatachalam, Neelima Yadav, Vickky Pandit, Sadhana Dubey, Sarah Latka, Hugo Villanueva, Scott H. Kaufmann, Arvind Panday
This study identifies FANCM as a synthetic lethal target in BRCA1-deficient breast cancer, showing it restricts structural genome instability and links replication stress to transcriptional changes.
bioRxiv · Sep 10, 2026 · PreprintCancer Biology