Cancer BiologybioRxivPreprint
FANCM restrains structural genome evolution and defines a synthetic lethal dependency in BRCA1-deficient breast cancer
Farah Ramadan, Sameer Bikram Shah, Ujwal Subedi…·Arvind Panday
This study identifies FANCM as a synthetic lethal target in BRCA1-deficient breast cancer, showing it restricts structural genome instability and links replication stress to transcriptional changes.
DOI 10.64898/2026.09.06.749689