High Precision Peptide-MHC Class I CARs Enhance In Vivo Killing ofTargeted CD8 T Cells to Prevent Type 1 Diabetes in Novel RIP-mOVA Model
M. Francis, Winston Hibler, Michael C. Yarnell, Neetigyata Singh, Ross M. Kedl, Matthew A. Burchill, Terry J. Fry, Maki Nakayama
This paper develops a peptide-MHC Class I CAR platform that enhances in vivo killing of antigen-specific CD8 T cells and prevents type 1 diabetes in a novel RIP-mOVA model.
bioRxiv · Nov 10, 2025 · PreprintImmunology