Ross M. Kedl

GPR182 is a lipoprotein receptor for dietary fat absorption

This study identifies GPR182 as a lipoprotein receptor that mediates dietary fat absorption and shows its role in obesity resistance.

IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

This study shows that IL-27 limits HSPC differentiation during infection and prevents stem cell exhaustion by reducing monocyte production and maintaining HSPC function.

High Precision Peptide-MHC Class I CARs Enhance In Vivo Killing ofTargeted CD8 T Cells to Prevent Type 1 Diabetes in Novel RIP-mOVA Model

This paper develops a peptide-MHC Class I CAR platform that enhances in vivo killing of antigen-specific CD8 T cells and prevents type 1 diabetes in a novel RIP-mOVA model.

An IL-12 mRNA-LNP adjuvant enhances mRNA vaccine induced CD8+ T cell responses

This study shows that adding IL-12 mRNA-LNPs to an mRNA vaccine enhances CD8+ T cell responses against model antigens and improves protection against infections and tumors.

The type I IFN-IL-27 axis promotes mRNA vaccine-induced CD8+ T cell responses

This study shows that IL-27, induced by mRNA-LNP vaccines, enhances CD8+ T cell responses through type I IFN signaling, improving vaccine efficacy against pathogens and tumors.

IL-27 Stablizes Myc-Mediated Transcription In Memory-Fated, Vaccine-Elicited CD8+ T Cells

Subunit vaccines induce CD8+ T cells with memory fate characteristics that maintain proliferative capacity via IL-27 receptor signaling during expansion.