Mechanosignaling Promotes Macrophage Apoptosis Resistance in Pulmonary Fibrosis via Metabolic Reprogramming
Chao He, Cristian Coarfa, Neftali Garcia, O Lebimoyo, Haiwei Gu, Elisa Ruiz-Echartea, Xiaoli Ji, Alan Waich, Juan D. Zuluaga, Lindsay J. Celada, Scott A. Ochsner, Neil J. McKenna, Jennifer L. Larson‐Casey, Sandeep Krishna Agarwal, Farrah Kheradmand, , Iván O. Rosas
This study shows that mechanical stiffness in fibrotic lungs promotes macrophage apoptosis resistance through metabolic reprogramming, contributing to fibrosis progression.
bioRxiv · Sep 28, 2026 · PreprintMolecular Biology