Neil J. McKenna

This study shows that mechanical stiffness in fibrotic lungs promotes macrophage apoptosis resistance through metabolic reprogramming, contributing to fibrosis progression.

This paper identifies compartment- and cell-specific molecular programs in preclinical familial pulmonary fibrosis using multi-omic profiling and finds these signatures are partially represented in peripheral blood.

This study shows that inhibiting macropinocytosis reduces fibrotic responses in lung fibroblasts and ameliorates pulmonary fibrosis in mice.

The paper uses single-cell transcriptomics to analyze an IPF cohort, revealing a transcriptional deficit refractory to current treatments and identifying STAT3 as a key regulator in the therapeutic gap.

This study identifies let-7 as a regulator of AT2 cell differentiation and fibrosis prevention by controlling oncogenic networks and epigenetic changes.

The paper shows MAGE-A4 promotes NSCLC by recruiting IgA+ plasma cells, reducing tumor burden and enhancing T cell activity.

The paper quantifies histone modifications and DNA methylation in mouse BAT under different cold conditions, revealing epigenetic changes linked to thermogenic response.

The paper identifies consensus transcriptional regulatory networks of coronavirus infections by analyzing differential gene expression across multiple CoV strains and validates key regulatory targets.

Signaling Pathways Project maps over 10,000 transcriptomic and ChIP-Seq experiments to signaling nodes and ranks node targets by meta-analysis (consensomes), validated against literature and bench assays.