Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism.
Laurent Maillet, Aurélie Fétiveau, Lisenn Lalier-Bretaudeau, Nena Martin, Sophie Barillé‐Nion, Catherine Guette, Fabien Gautier, Stéphane Télétchéa, Philippe Paul Juin
The paper shows that tail anchors of BCL-xL and PUMA modulate BH3-in-groove interactions, affecting BH3 mimetic antagonism and cell survival.
Nature Communications · Nov 22, 2025Peer-reviewedCell Biology