Therapeutic targeting of MYC- and MYCN-driven medulloblastoma with a novel MYC degrader molecule
Sin Wi Ng, Satyanarayana Gadde, Nga-yee Chung, Qian Wang, Larissa Doughty, Tracy L. Nero, Nisitha Jayatilleke, Janith A. Seneviratne, Daniel R. Carter, Marion K. Mateos, Maria Tsoli, David Simon Ziegler, Raelene Endersby, N Di Girolamo RK Kumar, Louis Chesler, , Glenn M. Marshall
This study identifies UNSW-SC-22 as a novel MYC/MYCN-targeting molecule that crosses the blood-brain barrier and shows potent preclinical efficacy in medulloblastoma.
bioRxiv · Jul 10, 2026 · PreprintCancer Biology