Author

Larissa Doughty

The University of MelbourneORCID 0000-0002-4929-528XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Michael W. ParkeriD· 2 shared Andrea C. Poblete Goycoolea· 1 shared Ashfaqul HoqueiD· 1 shared Ashley J. OvensiD· 1 shared Belamy B. CheungiD· 1 shared Benjamin R. Turner· 1 shared Bruce E. KempiD· 1 shared Ching‐Seng AngiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Michael W. ParkerORCID

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2 papers

Recent·Most cited

Fine tuning energy metabolism in skeletal muscle: Discovery of a novel autoinhibitory mechanism in the N-terminal extension of AMPKγ3

Ashley J. Ovens, Muhammad N.H. Khabib, Dingyi Yu, Naomi X.Y. Ling, William J. Smiles, Ashfaqul Hoque, Danise Ann Onda, Andrea C. Poblete Goycoolea, Meiqi Cao, Geoff X.Y. Zhang, Benjamin R. Turner, Larissa Doughty, Ching‐Seng Ang, Christopher R. Horne, John W. Scott, , Christopher G. Langendorf

This study identifies an autoinhibitory mechanism in the N-terminal extension of AMPKγ3 that regulates basal activity in skeletal muscle, offering a target for T2DM therapies.

bioRxiv · Aug 19, 2026 · PreprintBiochemistry

Therapeutic targeting of MYC- and MYCN-driven medulloblastoma with a novel MYC degrader molecule

Sin Wi Ng, Satyanarayana Gadde, Nga-yee Chung, Qian Wang, Larissa Doughty, Tracy L. Nero, Nisitha Jayatilleke, Janith A. Seneviratne, Daniel R. Carter, Marion K. Mateos, Maria Tsoli, David Simon Ziegler, Raelene Endersby, N Di Girolamo RK Kumar, Louis Chesler, , Glenn M. Marshall

This study identifies UNSW-SC-22 as a novel MYC/MYCN-targeting molecule that crosses the blood-brain barrier and shows potent preclinical efficacy in medulloblastoma.

bioRxiv · Jul 10, 2026 · PreprintCancer Biology