Plasmodium blood-stage induces trained immunity in hepatocytes
Elizabeth K. K. Glennon, Tinotenda Tongogara, Nhi NT Ho, Veronica I. Primavera, Noah Stegman, Ling Wei, Lola Velush, Cassandra Fieldson, Bogdan Velychko, Ashley Subijanto, Rafael B. Polidoro, Sean C. Murphy, Raj P. Kapur, Nana K. Minkah, Nathan W. Schmidt, , Alexis Kaushansky
This study shows that Plasmodium blood-stage infection primes hepatocytes to exhibit trained immunity, enhancing their response to subsequent challenges.
bioRxiv · Jul 23, 2026 · PreprintImmunology