Author

Sean C. Murphy

University of WashingtonORCID 0000-0002-2048-0131Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alejandro Téllez Calderón· 1 shared Alexis KaushanskyiD· 1 shared Amadou NiangalyiD· 1 shared Ashley Subijanto· 1 shared Bogdan Velychko· 1 shared Cassandra Fieldson· 1 shared Christine Y. WeiiD· 1 shared Daniel E. NeafseyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBioengineering

Alejandro Téllez Calderón

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Plasmodium blood-stage induces trained immunity in hepatocytes

Elizabeth K. K. Glennon, Tinotenda Tongogara, Nhi NT Ho, Veronica I. Primavera, Noah Stegman, Ling Wei, Lola Velush, Cassandra Fieldson, Bogdan Velychko, Ashley Subijanto, Rafael B. Polidoro, Sean C. Murphy, Raj P. Kapur, Nana K. Minkah, Nathan W. Schmidt, , Alexis Kaushansky

This study shows that Plasmodium blood-stage infection primes hepatocytes to exhibit trained immunity, enhancing their response to subsequent challenges.

bioRxiv · Jul 23, 2026 · PreprintImmunology

Systemic trafficking of mRNA lipid nanoparticle vaccine following intramuscular injection generates potent tissue-specific T cell response

Christine Y. Wei, Yining Zhu, Xiaoya Lu, Kailei D. Goodier, Di Yu, Xiang Liu, Joseph Choy, Alejandro Téllez Calderón, Jingyao Ma, Yunhe Su, Jinghan Lin, S.-H. Li, Jonathan P. Schneck, Sean C. Murphy, Hai‐Quan Mao

This study shows that mRNA lipid nanoparticles (LNPs) can be tailored to traffic to specific organs, enhancing tissue-specific T cell responses and vaccine efficacy.

bioRxiv · Apr 21, 2025 · PreprintBioengineering

Distinguishing new from persistent infections at the strain level using longitudinal genotyping data

William A. Nickols, Philipp Schwabl, Amadou Niangaly, Sean C. Murphy, Peter D. Crompton, Daniel E. Neafsey

The paper develops DINEMITES, a statistical method to distinguish new from persistent infections using longitudinal genotyping data, showing improved accuracy over simple rules.

bioRxiv · Feb 6, 2025 · PreprintGenomics