Cannabidiol Reduces Oxycodone Self-Administration While Preserving Its Analgesic Efficacy in a Rat Model of Neuropathic Pain
Adriaan W. Bruijnzeel, Azin Behnood‐Rod, Ranjithkumar Chellian, Wendi L. Malphurs, Robert M. Caudle, Marcelo Febo, Barry Setlow, Niall P. Murphy, John K. Neubert
This study shows that CBD reduces oxycodone self-administration in rats with neuropathic pain without diminishing oxycodone's pain-relieving effects.
Scientific Reports · Jan 11, 2026Peer-reviewedPharmacology & Toxicology