Disrupted Mitochondrial Copper Homeostasis Promotes Ferroptotic Stress, Senescence and MASLD Progression
Niansheng Ren, Liuyang Wang, Rajesh Kumar Dutta, David S. Umbaugh, Qiaojuan Zhang, Seh‐Hoon Oh, Dennis C. Ko, Ming Song, Anna Mae Diehl, Kuo Du
This study shows that mitochondrial copper deficiency drives MASLD by causing ferroptosis, senescence, and fibrosis, and that restoring copper homeostasis can alleviate disease.
bioRxiv · Jun 17, 2026 · PreprintPathology