Author

David S. Umbaugh

Duke UniversityORCID 0000-0002-5327-9020Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Anna Mae DiehliD· 1 shared Anup RamachandraniD· 1 shared Dennis C. KoiD· 1 shared Giselle Sánchez-GuerreroiD· 1 shared Hartmut JaeschkeiD· 1 shared Kuo DuiD· 1 shared Liuyang WangiD· 1 shared Ming SongiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPathology

Anna Mae DiehlORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJul 3, 2026

Adenosine A2B Receptor Activation: A Novel Therapeutic Strategy for Accelerating Liver Recovery After Acetaminophen Overdose

Giselle Sánchez-Guerrero, David S. Umbaugh, Nga T. Nguyen…·Anup Ramachandran

This study shows that activating the Adenosine A2B Receptor after acetaminophen overdose accelerates liver recovery by enhancing lipid metabolism and immune responses.

DOI 10.64898/2026.06.29.735109

mouseexperimental assay

𝕏 PostBluesky

PathologybioRxivPreprintJun 17, 2026

Disrupted Mitochondrial Copper Homeostasis Promotes Ferroptotic Stress, Senescence and MASLD Progression

Niansheng Ren, Liuyang Wang, Rajesh Kumar Dutta…·Kuo Du

This study shows that mitochondrial copper deficiency drives MASLD by causing ferroptosis, senescence, and fibrosis, and that restoring copper homeostasis can alleviate disease.

DOI 10.64898/2026.06.15.731916

mouseexperimental assay

𝕏 PostBluesky